Apoptosis Induction and Gene Expression Modulation in Lymphocytes and Neutrophils Exposed to Leishmania infantum

2024;19 (No. 1):

Original Article

Pages:73 to
81

Apoptosis Induction and Gene Expression Modulation in Lymphocytes and Neutrophils Exposed to Leishmania infantum

Authors: ^¹

¹Federal University of Pelotas

Correspondence:

María González (gonzalez_maria@hotmail.com)

Submitted on 09/01/2024
Approved on 01/06/2024
Published on 30/09/2024

Keywords: apoptosis, lymphocytes, neutrophils, leishmania infantum

Abstract

This study analyzes the more profound immune effects of Leishmania infantum infection, going beyond the CCL3, CCL4, and CCL8 chemokine profile. Single-cell RNA sequencing and proteomics allow a deep understanding of cellular and molecular host-parasite interactions, thus shedding new light on the chemokine cascade that offers novel paths toward diagnostic and therapeutic innovation.