Abstract

Polycystic ovarian syndrome (PCOS) is the most common metabolic and endocrine disorder among women of reproductive age, owing to its multi-factorial genetic basis. This research examines the association between polymorphisms in the CYP2C8 gene, namely rs10509681 found in the exon region and rs1058932 located in the 3-UTR region, with susceptibility to PCOS. Blood samples were analyzed in 48 subjects, consisting of 24 PCOS patients and 24 healthy controls, aged between 20 and 40 years. Sequencing results revealed three genotypes: GG, GA, and AA, at the rs1058932 site, and two genotypes: TT and TC, at the rs10509681 site. Statistical analyses showed that although there were no significant differences in genotype frequency in both groups, particular genotypes had higher odds for PCOS. More noteworthy is that GA genotype and T allele increased the risk while GG and AA genotypes were associated with protective tendencies. It describes several potential genetic contributors to PCOS while bringing focus to further exploring these associations within larger populations.