Perinatal Inflammatory Biomarkers Predicting Neonatal Complications in High-Risk Pregnancies Assessment
Keywords:
Perinatal inflammation, inflammatory biomarkers, high-risk pregnancy, neonatal complications, C-reactive protein, interleukin-6, neonatal sepsis, respiratory distress syndrome, neonatal outcomes.Abstract
Background: High-risk pregnancies are frequently associated with inflammatory responses that can adversely affect fetal development and neonatal health. Perinatal inflammatory biomarkers have emerged as potential predictors of neonatal complications, enabling earlier identification of at-risk infants.
Objective: To assess the predictive value of perinatal inflammatory biomarkers in identifying neonatal complications among high-risk pregnancies.
Methodology: A retrospective observational assessment was conducted using data from 120 high-risk pregnancies. Maternal and neonatal inflammatory biomarkers, including C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin levels, were evaluated. Associations between biomarker concentrations and neonatal outcomes were analyzed using comparative statistical methods.
Findings: Elevated inflammatory biomarker levels were significantly associated with adverse neonatal outcomes. Neonates born to mothers with high CRP and IL-6 levels demonstrated increased incidences of respiratory distress syndrome (32%), neonatal sepsis (24%), and admission to neonatal intensive care units (41%). Biomarker-based prediction models achieved an overall predictive accuracy of 84%, indicating strong utility in risk stratification. Increased inflammatory activity was also correlated with lower birth weight and prolonged hospitalization duration.
Conclusion: Perinatal inflammatory biomarkers are valuable predictors of neonatal complications in high-risk pregnancies. Their incorporation into prenatal and perinatal assessment protocols may facilitate early intervention, improve neonatal monitoring, and enhance clinical outcomes through targeted management strategies.
