Preformulation Studies Of Mixed Hydrotropic Solid Dispersion Of Simvastatin

Abstract

This research work focused on pre-formulation and characterization studies of mixed hydrotropic solid dispersion of Simvastatin prepared by solvent evaporation method. Various hydrotropic agents including Nicotinamide, Sodium Benzoate, Sodium Citrate, and PEG 6000 were employed to improve aqueous solubility of Simvastatin. The drug and formulations were evaluated using organoleptic studies, melting point analysis, UV spectroscopy, FTIR, DSC, PXRD, and equilibrium solubility studies. The optimized formulation showed improved solubility and reduced crystallinity. The results confirmed the suitability of mixed hydrotropic solid dispersion approach for enhancing physicochemical performance of Simvastatin.