Synthysis, Characterization, And Antioxidant Activity Of 1,2,3-Triazole Derivatives From 5,6 -Isopropylidene-L-Ascorbic Acid
DOI:
https://doi.org/10.67440/ahj.v21i2.1282Keywords:
1,2,3-triazoles, 5,6-isopropylidene-L- ascorbic acid, azide, Sulfadiazine derivatives, Click chemistry, Azo comound.Abstract
The need to develop powerful antioxidant agents capable of combating resistant infections without compromising human health has motivated significant research for novel antioxidant compounds[1].
In this study two of Sulfadiazine Azo azides derivatives (2,4) are reacted with compound (A) 5,6- isopropylidene-2,3-di-O-propargyl-L-ascorbic acid to prepare a new 1,2,3-triazole derivatives (A2 and A4) derivatives are synthesized by Copper (1) catalyzed azide-alkyne cycloaddition reaction (Click Chemistry)2, Following the synthesis, the de-protected analogs (A22 and A44) were obtained by removing the acetal groups using Iodine in methanol. All synthesized compounds were structurally distinguished using FT-IR, 1H-NMR, 13C-NMR, and TLC techniques.
The synthesized compounds A4,A44 exhibited outstanding antioxidant efficiency with IC_{50} values below 25 \ \mu\text{g/mL}, significantly outperforming the standard Ascorbic acid and highlighting their promising potential as potent biomaterials.
