Pancreatic Adenocarcinoma With Hyperplastic Polyps Seen in Duodenum and Rectum an Analysis To Rule Out Juvenile Polyposis Syndrome

Abstract

Polyposis syndromes are of several types, they can be either inherited or acquired. Most of them are associated with increased colorectal cancer. Rare type of juvenile polyposis syndrome is associated with pancreatic cancer. JPS is characterized by multiple hamartomatous (hyperplastic) juvenile polyps in the stomach, small intestine and colon. Juvenile polyposis coli has polyposis restricted to colon. Whereas generalized juvenile polyposis has polyps throughout the gastro intestinal tract and may rarely be associated with pancreatic cancer. It has mutation in SMAD4 gene, located in chromosome 18q21 also called as DPC4. It is deleted in pancreatic carcinoma. Here we have a case of hyperplastic polyp in duodenum and rectum along with intestinal type of adenocarcinoma of pancreas in a 62 year old male.