Unraveling The Mystery: A Case of Pyrexia Of Unknown Origin Due To Splenic Marginal Zone Lymphoma
Keywords:
PUO, Splenic lymphoma, Marginal zone lymphoma, Fever of unknown origin, Splenomegaly.Abstract
Background: Pyrexia of unknown origin (PUO) continues to pose a diagnostic challenge despite advances in imaging and laboratory diagnostics. The etiological spectrum includes infections, inflammatory disorders, malignancies, and miscellaneous causes.
Case Presentation:A 28-year-old female presented with low-grade continuous fever for one month without localizing symptoms. Extensive evaluation including laboratory tests, cultures, and imaging was performed.
Investigations:Initial investigations were inconclusive. Imaging revealed splenomegaly with focal lesions, prompting further evaluation with contrast-enhanced imaging and histopathological confirmation.
Conclusion:Splenic marginal zone lymphoma, though rare, should be considered in prolonged unexplained fever. A structured diagnostic approach and judicious use of imaging are essential.
