Construction Strategies To Achieve New Supreme Series Of Poly Heterocyclic System Incorporating Arylidene Imidazolone

Abstract

Poly heterocyclic system received a great deals of attention due to it's wide applications in the pharmacists, and, agrochemical dyes and advance polymers helds, especially when it's involving aza ring such as arylidene imidazolone which are versatile  organic unite that well known as core structure in fluoresent proteins, like GEP and as powerful fluoryanic dyes for Cell imaging, Sensors for metal ions (Zn+Cd), as well as, potential anticancer agent due to the tunable photo physical and biological properties. Basically this organic unite used in this work to perform poly heterocyclic system involving 1, 2, 3- oxadiazol, 4-arylidine imidazolone and aryl ring. First of all, the arylidene imidazolone  (3&4) were prepared thorough the reaction of arylidene oxazolone  (1&2) with semicarbazide in acidic media then it was converted to the corresponding Schiff bases (5&6) via the reaction with p-hydroxy benzaldehyde. These Schiff bases then underwent intracyclization reaction by the action of acetic anhydride to offered the target compounds represented by poly heterocyclic system including both of 4-arylidin imidazolone and 1,3,4 -oxadiazoline  (7&8).