Epigenetics of Neurodegenerative Disorders

Abstract

Neurodegenerative diseases are dreaded throughout the world due to their lethality and sporadic nature. The sporadic nature and slow progression of these diseases make their early detection and hence clinical management difficult. The advances in the field of epigenetics have given people hope as at molecular level the aberrancy of epigenetic regulators helps in the progression and development of these disease. The major researches have been done in understanding the epigenetic nature of these disease and several hallmark epigenetic alterations have been recorded for each disease. These major breakthroughs have helped us in understanding the neuropathy at molecular level and countering it more effectively with the drugs and clinical management. In this review we summarize the alterations in various epigenetic modulators’ leading to the pathogenesis of various neurodegenerative diseases. We also tried to summarize the various environmental and molecular factors which influence the epigenetic machinery and increase or induce the pathogenesis of neurodegenerative disease.