Formulation Development and Evaluation of Kaolin – Curcumin Haemostatic Wound Healing Ointment

Abstract

Background: Rapid control of bleeding and support of subsequent wound repair are important objectives in topical wound management. The supplied research draft describes a haemostatic wound-healing formulation combining kaolin, curcumin and a semisolid ointment base. Objective: To develop and systematically evaluate a kaolin–curcumin ointment intended to provide haemostatic and wound-healing activity. Materials and Method: Six prototype batches (F1–F6) were prepared by fusion using liquid paraffin, cetostearyl alcohol, hard paraffin and white soft paraffin, with graded kaolin and curcumin concentrations. The supplied study identifies F5 as the optimized batch, containing 5% liquid paraffin, 5% cetostearyl alcohol, 5% hard paraffin, 64% white soft paraffin, 20% kaolin and 1% curcumin. The research expands the evaluation framework to include appearance, homogeneity, pH, viscosity/rheology, spreadability, extrudability, washability, content uniformity.

Results and Discussion: The research reports that F5 was selected as the optimized formulation and that the formulated cream/ointment showed good spreadability, viscosity and with good potential to use.

Conclusion: F5 provides a potential formulation for wound healing and antimicrobial properties as compared with standard drug and there is future perspective of further detailed evaluation.