The Impact of Gonadotropin Hormones on Toxoplasma Gondii Infection in Women With Polycystic Ovarian Syndrome

Abstract

Recent research tell us that infectious pathogens may play a role in the development of polycystic ovarian syndrome (PCOS), especially through immunological dysregulation. Toxoplasma gondii (T. gondii), an intracellular protozoan parasite, has been linked to various immune-mediated diseases. This study looked at the connection between gonadotropin hormones and a T. gondii infection in PCOS-affected individuals. The study had 90 women with PCOS and toxoplasmosis and 90 healthy controls. The serum levels of estrogen (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (TST), immunoglobulin G (IgG), and immunoglobulin M (IgM) were measured. Women with PCOS and toxoplasmosis had considerably greater levels of LH, E2, TST, LH/FSH ratio, IgG, and IgM, as well as significantly lower FSH levels, compared to controls (p = 0.001). Furthermore, positive relationships were found between the LH/FSH ratio and factors such as LH, IgG, and IgM levels, as well as age and number of abortions in infected PCOS patients, while a significant negative association was found with FSH levels. These data imply that T. gondii infection may worsen hormonal and immunological problems in PCOS patients.