Apoptosis Induction and Gene Expression Modulation in Lymphocytes and Neutrophils Exposed to <i>Leishmania infantum</i>

Abstract

This study analyzes the more profound immune effects of Leishmania infantum infection, going beyond the CCL3, CCL4, and CCL8 chemokine profile. Single-cell RNA sequencing and proteomics allow a deep understanding of cellular and molecular host-parasite interactions, thus shedding new light on the chemokine cascade that offers novel paths toward diagnostic and therapeutic innovation.