Green Synthesis of Bioactive Nanocomposites and Their Antioxidant Potential in Adolescent Health Applications

Abstract

Green-synthesized bioactive nanocomposites have emerged as promising multifunctional materials that combine sustainable fabrication with enhanced biological performance. This review critically examines recent advances in the green synthesis of bioactive nanocomposites and their antioxidant potential, with particular emphasis on applications relevant to adolescent health. The review discusses environmentally friendly synthesis strategies utilizing plant extracts, microorganisms, and other biological resources, together with the influence of synthesis parameters on nanocomposite properties and functionality. It further summarizes the composition, physicochemical characteristics, and characterization techniques that determine biological performance, while highlighting the molecular mechanisms responsible for antioxidant activity and the methods used for antioxidant evaluation. Potential biomedical applications, including nutraceuticals, wound healing, oral healthcare, dermatology, targeted drug delivery, and wearable health technologies, are comprehensively reviewed. Safety, toxicity, biocompatibility, and regulatory considerations are also examined to identify key barriers to successful clinical translation. Additionally, emerging developments in artificial intelligence, precision nanomedicine, and multi-omics technologies are discussed as promising approaches for optimizing nanocomposite design and accelerating personalized healthcare solutions. Although considerable progress has been achieved, further standardization, long-term safety assessment, and interdisciplinary collaboration are required to translate these sustainable nanomaterials into clinically effective interventions. Green-synthesized bioactive nanocomposites have significant potential to support future antioxidant-based strategies for adolescent health and broader biomedical applications.